The Greenville Chorale was organized in 1961 as the "Rotary Civic Chorale" by the Rotary Club of Greenville. Beginning with forty-five singers, the Chorale's mission was to provide the Upstate with a strong, symphonic community chorus. So well-received was this effort, that seven years later (1968) the "Greenville Civic Chorale Association" was chartered and the Chorale became self-sustaining. In 1987, the official title was changed to The Greenville Chorale.

Since 1961, The Greenville Chorale has grown in size to a current roster of over 200 singers from Greenville, Spartanburg, Anderson, Pickens, Laurens, Oconee, Clemson, Greer, Simpsonville, Mauldin, Travelers Rest, and Easley.

The Greenville Chorale brings to life the world's greatest works for symphonic choruses, and for its efforts, it consistently receives recognition as a premier choral group in the Southeast.